EFG1 — Aspergillus nidulans FGSC A4

Summary

ANIA_04270 (EFG1, AnEFG1) encodes the Pan1 protein, which contains EF-hand, EH, and WH2 domains and is associated with actin binding, calcium ion binding, and protein binding/bridging. In Aspergillus nidulans, AnEFG1 is associated with conidiophore development, ascospore formation, filamentous growth, endocytosis, endosomal transport, and morphogenesis. The protein localizes to the endosome membrane, actin patch, plasma membrane, and cytoplasm. Phenotypic associations include abnormal bipolar and axial budding patterns, decreased cytokinesis rate, delayed autophagy, increased necrotic cell death, absent cell fusion, abnormal shmoo formation, and defective hyperosmotic stress resistance and innate thermotolerance. Studies of related genes in other species link the EFG1 family to endocytosis, cell cycle progression, and prion inheritance.