RIM20 — Aspergillus nidulans FGSC A4

Summary

ANIA_04351 (symbol RIM20, preferred name AnRIM20) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes a protein containing BRO1 and ALIX_V domains, placing it in the BRO1 superfamily. This gene is associated with regulation of protein-nucleus import, endocytosis, proteolysis, signal transduction, and the ESCRT III complex and endosome. It is associated with activation of penicillin anabolism and regulation of secondary metabolite biosynthesis, as well as filamentous growth in response to pH, host invasion, and cellular responses to lithium ions and neutral pH. AnRIM20 is also associated with abnormal pseudohyphal growth, increased ionic stress resistance, decreased nutrient uptake, and altered vacuolar transport and autophagy. Studies of related genes in other species link the family to pH-response regulation and calcium sensitivity.