HXKA — Aspergillus nidulans FGSC A4

Summary

ANIA_04255 (HXKA, AnHXKA) on chromosome 2 encodes a hexokinase with N-acetylglucosamine kinase, glucosamine kinase, mannokinase, glucokinase, and fructokinase activities, and binds ATP and D-glucose. It is associated with canonical glycolysis, the pentose-phosphate shunt, glucose 6-phosphate metabolism, and the breakdown of glucose, fructose, mannose, glucosamine, and N-acetylglucosamine. The gene is linked to regulation of proteolysis and phenotypic switching, fungal-type cell wall biogenesis, chitin anabolism, development of symbiont in host, and adhesion of symbiont to host. Its product localises to the cytosol, nucleus, and mitochondria. Related genes in other species are linked to reduced virulence and unaffected pathogenicity.