ADH1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03741 (symbol ADH1, also known as AnADH1) on chromosome 2 encodes an alcohol dehydrogenase (EC 1.1.1.1) with aldo-keto reductase (NAD) activity and zinc binding, belonging to the ADH_Zn_CS and ADH-like domain families. The gene is associated with alcohol metabolism, acetaldehyde breakdown, ethanol breakdown, ethanol fermentation, and fermentation, as well as threonine breakdown, carbohydrate metabolism, and aflatoxin anabolism. It is linked to the cellular response to farnesol. The encoded product is localized to the cytoplasm, mitochondrial lumen, extracellular region, and fungal biofilm matrix. Studies of related genes in other species link the family to species such as Verticillium dahliae and Fusarium oxysporum f. sp. cubense TR4, though these associations are not established for A. nidulans itself.