RRS1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03745 (symbol RRS1, AnRRS1) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a ribosome biogenesis regulatory protein with a Ribosom_reg domain and ssRNA binding activity. The gene is associated with ribosomal large subunit biogenesis, ribosome assembly, rRNA processing, and endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from the tricistronic transcript. The product localises to the nucleolus, nucleus, and preribosome large subunit precursor. AnRRS1 is associated with increased anaerobic growth, increased alkaline pH resistance, increased desiccation resistance, increased polyploidy, decreased pheromone production, absent pheromone sensitivity, absent mating response, abnormal pseudohyphal growth, abnormal endocytosis, abnormal cytoskeleton morphology, delayed cell cycle progression, arrested M phase, and sterility.