FHL1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03932 (FHL1, also known as AnFHL1) encodes a proteasome endopeptidase complex component with threonine endopeptidase activity (EC 3.4.25.1), belonging to the Pept_T1A_subB and proteasome subunit beta-type families. In Aspergillus nidulans, this gene is associated with proteasomal protein catabolic processes, 20S proteasome assembly, and proteolysis. It is linked to peroxisome and mitochondria localization, urate transport, the glyoxylate cycle, TCA cycle, CoA metabolism, biotin and penicillin anabolism, secondary metabolism, and meiosis. Phenotypic associations include abnormal cell cycle progression (increased G2/M phase duration, delayed M phase), increased mutation frequency, abnormal transposable element transposition, abnormal peroxisomal and Golgi morphology, increased polyploidy, and increased stationary phase survival. The gene product localizes to the proteasome core complex, peroxisome, nuclear envelope, cytoplasm, cytosol, and nucleus.