GBP2 — Aspergillus nidulans FGSC A4

Summary

ANIA_03937 (GBP2, AnGBP2) on chromosome 2 of Aspergillus nidulans encodes an RNP domain protein with RNA-binding, poly(A)-binding, poly(U)-binding and mRNA 3′-UTR-binding activities. The gene is associated with nuclear mRNA surveillance, poly(A)+ mRNA export from the nucleus, RNA splicing, mRNA transport and processing, regulation of translation, cell cycle modulation (S phase and mitosis), and methylation. The encoded protein localises to the cytoplasm, nucleus, stress granules, spliceosome complex and protein aggregate centres. Phenotypic associations link GBP2 to abnormal prion inheritance and formation, absent spindle morphology, increased G1/S and S-phase progression, decreased lifespan, absent meiosis and innate thermotolerance, increased X-ray resistance, decreased anaerobic and fermentative growth, and altered RNA modification and nuclear transport. Studies of related genes in other species connect the family to oxidative stress response.