GAS1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03730 (GAS1, AnGAS1) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a glucanosyltransferase with 1,3-beta-glucanosyltransferase activity, belonging to the glycoside hydrolase superfamily and containing an X8 domain. The gene is associated with fungal-type cell wall assembly and 1,3-beta-glucan metabolism, as well as lipid modification, cellular responses to pH and calcium ions, cell-substrate adhesion, biofilm formation, host invasion, development of symbiont in host, division septum assembly, cell morphogenesis, and filamentous growth. The product localizes to the cell septum edging, primary cell septum, vesicle, cellular bud membrane and scar, external side of plasma membrane, growing cell tips, lipid raft, and sites of polarized growth. Phenotypic associations include altered alkaline pH resistance, mating response, filamentous growth, mitotic recombination, and chronological lifespan. Studies of related genes in other species link the family to reduced virulence and leaf necrosis.