ADE2 — Aspergillus nidulans FGSC A4

Summary

AnADE2 (ANIA_03626) on chromosome 2 of Aspergillus nidulans encodes a protein with a PurE domain and PurK domain, and has phosphoribosylaminoimidazole carboxylase activity (EC 4.1.1.21), ATP binding, and metal binding. The gene is associated with purine base metabolism, purine base anabolism, adenine anabolism, 'de novo' IMP anabolism, hypersensitivity, and chromatin modeling, and localises to the cytosol. It is associated with phenotypes including premature apoptosis, increased apoptosis, decreased gamma ray resistance, abnormal cell shape, decreased sporulation, abnormal budding pattern, decreased autophagy, increased mutation frequency, and increased protein secretion. Related genes in other species are linked to abnormal colony color, loss of pathogenicity, and reduced virulence.