CIG2 — Aspergillus nidulans FGSC A4

Summary

ANIA_03648 (CIG2, nimE) on Aspergillus nidulans chromosome 2 encodes a cyclin A/B-like protein with cyclin-box domains and cyclin-dependent protein serine/threonine kinase activator and regulator activities. It is associated with mitotic cell cycle phase transitions, particularly G1/S and G2/M transitions, and regulation of CDK activity. The gene is linked to negative regulation of ascospore formation and meiotic cell cycle, as well as regulation of reciprocal meiotic recombination and cell cycle switching between mitotic and meiotic programs. Localization evidence connects the product to the microtubule organizing center, spindle pole bodies, CDK holoenzyme, meiotic and mitotic spindles, and nuclear periphery. Phenotypic associations include delayed metaphase-anaphase transition, G2/M arrest, abnormal mitochondrial genome maintenance, increased chitin deposition and enzymatic resistance, altered carbon and nitrogen utilization, decreased respiratory growth and heat sensitivity, reduced replicative and chronological lifespan, and impaired vegetative growth and competitive fitness.