GCN5 — Aspergillus nidulans FGSC A4

Summary

ANIA_03621 (GCN5, AnGCN5) on Aspergillus nidulans chromosome 2 encodes a protein with a GNAT domain and a bromodomain, and is annotated as a histone acetyltransferase (EC 2.3.1.48) and a transcriptional co-regulator. It is associated with histone reader activity for H3K56ac, H4K12ac, and H4K16ac, and with histone acetyltransferase activity for H3K9, H3K14, H3K18, and H4, as well as crotonyltransferase activity. The gene is associated with conidiophore development, carbon catabolite repression, heterochromatin boundary formation, DNA repair-dependent chromatin remodeling, secondary metabolism, and the TCA cycle. It localizes to chromatin, the nucleus, and complexes including ADA, SALSA, and SWR-C. Phenotypic associations link GCN5 to increased sporulation, altered cell cycle progression, abnormal mitophagy, increased transposable element transposition, and increased carbon source utilization. Related genes in other species connect the family to altered virulence.