CCC2 — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene CCC2 (AnCCC2) on chromosome 2 encodes a P-type ATPase with heavy-metal-associated domains, classified as EC 7.2.2.8 and annotated with P-type monovalent, divalent copper, manganese, and calcium transporter activities, as well as copper binding and ATP hydrolase activity. It is associated with copper export, copper and manganese ion homeostasis, pigment metabolism in developmental pigmentation, cell pH regulation, proton export, calcium ion membrane transport, and macroautophagy. The encoded product localizes to the Golgi membrane, ER, plasmalemma, endomembrane system, lipid raft, and extracellular vesicle. Phenotypic associations include absent spore germination, abnormal spore wall formation, decreased autophagy, increased biofilm formation, increased telomere length, and altered protein secretion and transport. Studies of related genes in other species link the family to copper homeostasis and oxidative stress response.