CLR-2 — Aspergillus nidulans FGSC A4

Summary

ANIA_03369 (CLR-2, AnCLR-2) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a Zn(II)2Cys6 transcription factor belonging to the fungal secondary metabolite regulator family, with DNA-binding transcription activator activity and O-glucosyl hydrolase activity. The gene is associated with positive regulation of cellulose breakdown, patulin anabolism, and thiamin biosynthesis, as well as galactose metabolism, fermentation, secretion, and RNA-dependent gene silencing. It is linked to transcriptional regulation by RNA polymerase II, including positive regulation and galactose-responsive upregulation. The encoded protein localises to both the nucleus and cytosol. Related genes in other species encode Zn(2)-C6 fungal-type domain-containing proteins.