CLM2 — Aspergillus nidulans FGSC A4

Summary

ANIA_03394 (CLM2, AnCLM2) in Aspergillus nidulans FGSC A4 encodes a cytochrome P450 monooxygenase with heme and iron binding, oxidoreductase activity, and aflatoxin B synthase activity. It is associated with the biosynthesis of fumagillin, ergosterol, terpenoids, aflatoxin, and other mycotoxins, as well as with lipogenesis, fermentation, sexual reproduction, meiosis, endocytosis, autophagy, and hypersensitivity. The gene is linked to numerous phenotypes including decreased micronucleophagy, nucleophagy, and ribophagy; abnormal cell cycle progression through G2/M and S phases; increased cell death; decreased invasive growth; arrested vegetative and exponential-phase growth; increased fermentative metabolism; and abnormal plasma membrane morphology, endoplasmic reticulum distribution, and Golgi distribution. Related genes in other species are linked to protein content and hypervirulence.