FHPA — Aspergillus nidulans FGSC A4

Summary

ANIA_03522 (FHPA, AnFHPA) on Aspergillus nidulans chromosome 2 encodes a protein with nitric oxide dioxygenase [NAD(P)H] activity (EC 1.14.12.17), oxygen binding, cytochrome-b5 reductase activity acting on NADH and NAD(P)H, NADH dehydrogenase activity, transferase activity, FAD binding, heme binding, and metal binding. The protein contains globin, globin-like, globin/proto, oxidoreductase FAD/NAD-binding, riboflavin synthase-like beta-barrel, FAD-binding FR-type, and FNR nucleotide-binding domains. AnFHPA is associated with nitric oxide breakdown, alternative respiration, mcm5 modification, cellular response to nitrosative stress, protein histidyl modification to diphthamide, response to toxic substance, cellular detoxification of nitrogen compound, gluconeogenesis, heterotrophy, sterigmatocystin anabolism, filamentous growth of a population of unicellular organisms, detoxification, and filamentous growth. It localizes to the mitochondrial outer membrane, mitochondria, cytoplasm, cytosol, and nucleus. AnFHPA is associated with absent protein/peptide accumulation, decreased fermentative and respiratory metabolism, increased pheromone sensitivity, increased mating response, absent mitochondrial genome maintenance, increased flocculation, petite, abnormal budding, abnormal protein/peptide modification, increased autophagy, decreased gamma ray resistance, increased hyperosm