PRI1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03033 (PRI1, also known as AnPRI1) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a protein with a DNA primase small subunit domain and DNA-directed RNA polymerase activity (EC 2.7.7.-), and is associated with metal binding. AnPRI1 is associated with DNA replication initiation, primer synthesis, methylation, and chromatin remodelling, and localises to the nucleus, cytoplasm, chromatin, and the alpha DNA polymerase:primase complex. The gene has been linked to numerous cell cycle phenotypes, including abnormal progression through G1/S phase transition, S phase arrest or delay, and altered meiotic recombination and meiosis. It is also connected to decreased resistance to UV, X-ray, gamma radiation, and ionising radiation, reduced anaerobic growth, abnormal chromosome segregation, and decreased mitochondrial genome maintenance.