OEFC — Aspergillus nidulans FGSC A4

Summary

ANIA_03075 (symbol OEFC, also known as AnOEFC) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a Zn(2)-C6 fungal-type domain-containing protein, a DNA-binding transcription factor that binds RNA polymerase II cis-regulatory regions and zinc. This gene is associated with the regulation of transcription by RNA polymerase II, including positive regulation, and with DNA-dependent transcription. It is associated with the upregulation of conjugation with cellular fusion and with the cellular response to xenobiotic stimulus. The encoded protein localises to the nucleus, specifically to mating-type region heterochromatin and centric heterochromatin. Studies of related genes in other species, such as Fusarium oxysporum and Verticillium dahliae, connect the OEFC family to similar regulatory roles, though these associations are not yet established in A. nidulans.