ATF1 — Aspergillus nidulans FGSC A4

Summary

ANIA_02911, symbol ATF1 (AnATF1), encodes a basic leucine zipper (bZIP) transcription factor, AtfB, with DNA-binding transcription factor activity and sequence-specific DNA binding for RNA polymerase II. Located in the nucleus, this gene is associated with responses to fungi, upregulation of aflatoxin anabolism, autolysis, stress-activated MAPK cascades, cellular homeostasis, and regulation of signal transduction. It is linked to cellular responses to copper, hydrogen peroxide, heat, and oxidative stress, as well as apoptotic processes, cell death, spore formation, filamentous growth, invasive growth, and negative regulation of transcription by RNA polymerase II. Studies of related genes in other species connect the family to oxidative stress response, calcium and acid sensitivity, and reduced virulence.