PACC — Aspergillus nidulans FGSC A4

Summary

ANIA_02855, symbol PACC (also known as AnPACC, AnRIM101, RIM101) on chromosome 6 of Aspergillus nidulans FGSC A4, encodes a transcription factor of the pacC/RIM101 family that binds sequence-specific DNA. This gene is associated with the regulation of pH, including responses to both basic pH and carbon starvation, as well as with penicillin anabolism, autolysis, chemotropism, cell differentiation, and carbon catabolite repression. It has also been linked to sugar content and to the regulation of binding, primary metabolism, and nonsense-mediated mRNA decay. The encoded protein localises to both the cytoplasm and nucleus. Studies of related genes in other fungi link the pacC/RIM101 family to reduced virulence and to diseases such as aspergillosis and pulmonary aspergillosis.