PMC1 — Aspergillus nidulans FGSC A4

Summary

AnPMC1 (ANIA_02827) on chromosome 6 of Aspergillus nidulans encodes a calcium-transporting ATPase of the P-type ATPase IIB family. The gene is associated with multiple cation transport activities, including calcium, potassium, sodium, and manganese ion transport, as well as proton-transporting ATPase activity. It is linked to cellular processes such as calcium, potassium, and sodium ion homeostasis, ion export from the cell, cell pH reduction, and response to unfolded protein. The product localises to the plasma membrane, vacuolar membrane, Golgi membrane, ER membrane, and nuclear envelope. AnPMC1 has been connected to calcium sensitivity and numerous phenotypes including abnormal Golgi distribution and morphology, absent spore germination, decreased micronucleophagy, altered endocytosis and vacuolar transport, increased ionic stress resistance, and abnormal cell cycle progression. Studies of related genes in other species link the family to virulence and pathogenicity.