acvA — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene acvA (ANIA_02621) on chromosome 6 encodes delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (ACVS), a multidomain enzyme with thioesterase, condensation, and acyl-carrier protein domains that catalyses the committed step in penicillin biosynthesis (EC 6.3.2.26). The gene is associated with penicillin anabolism, regulation of penicillin anabolism, and the glucose effect. It is linked to amino acid activation for nonribosomal peptide biosynthetic process, primary and secondary metabolism, fermentation, and signal transduction. The product localises to the cytoplasm, cytosol, and vacuolar membrane. Related genes in other species, including tyrocidine synthetase 1 and the mpbA/mpcA gene products, connect the family broadly to nonribosomal peptide synthesis.