penDE — Aspergillus nidulans FGSC A4
Summary
ANIA_02623 (penDE) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes isopenicillin-N acyltransferase (EC 2.3.1.164), a member of the peptidase C45 family. This enzyme is associated with beta-lactam antibiotic biosynthesis, specifically penicillin anabolism and its regulation. The gene product is linked to carbon catabolite repression, the glucose effect, primary and secondary metabolism, and fermentation. It is also connected to secretion and localises to the peroxisomal lumen. Studies of related genes in other species link the family to acyl-CoA:6-aminopenicillanic-acid-acyltransferase activity.
Annotations
- Chromosome
- 6
- Related genes
- aatA, penDE
- GO terms
- Catabolite Repression, Carbon Catabolite Repression, glucose effect, beta-lactam antibiotic anabolism, Secretion, primary metabolism, regulation of penicillin anabolism, antibiotic anabolism
- Publications
- PMID:9858535, PMID:16713314, PMID:10422583, PMID:10422582, PMID:10422579, PMID:7847890, PMID:15719552, PMID:8544821