HXK1 — Aspergillus nidulans FGSC A4

Summary

AnHXK1 (ANIA_02638) on chromosome 6 of Aspergillus nidulans encodes a hexokinase with glucosamine, mannokinase, glucokinase and fructokinase activities, and binds ATP and D-glucose. It is associated with canonical glycolysis, the pentose-phosphate shunt, glucose 6-phosphate metabolism, fructose and mannose metabolism, fructose uptake, and cell glucose homeostasis. The protein localises to both the cytosol and mitochondria. Phenotypic associations link AnHXK1 to abnormal cell cycle progression through G1/S and G2/M phases, increased M phase progression, delayed metaphase-anaphase transition, decreased entry into G0, decreased chronological lifespan, increased anaerobic growth, abnormal fermentative and respiratory metabolism, absent desiccation resistance, increased freeze-thaw resistance, decreased cell death, abnormal nuclear transport, decreased pexophagy, and altered Golgi and endoplasmic reticulum distribution. Studies of related genes in other species connect the family to biomass yield, alkali sensitivity, oxidative stress response, and reduced virulence.