hxnT — Aspergillus nidulans FGSC A4

Summary

ANIA_02682 (symbol hxnT) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a hypothetical oxidoreductase belonging to the Oye-like family, with domains including OxRdtase_FMN_N and Aldolase_TIM. The gene product exhibits 2-enoate reductase activity, oxidoreductase activity acting on CH-CH donors with NAD or NADP as acceptor, NADPH dehydrogenase activity, and FMN binding. It is also associated with hormone, estrogen, and steroid binding. The protein localises to the hyphal cell wall, fungal-type vacuole, and cytosol. Biologically, hxnT is linked to nicotinate breakdown, steroid metabolism, indole alkaloid anabolism, alkaloid metabolism, and apoptotic processes. Related genes in other species, including 12-oxophytodienoate reductases and old yellow enzyme (OYE1), connect the family to oxidoreductase activities (EC 1.3.1.31, 1.3.1.100, 1.6.99.1) and to plant pathogens such as Verticillium dahliae and Fusarium oxysporum strains.