AMD2 — Aspergillus nidulans FGSC A4

Summary

AnAMD2 (ANIA_02662) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a protein with amidase and fatty acid amide hydrolase activity, also annotated with glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity and ATP binding. The product belongs to the amidase domain family and is associated with glutaminyl-tRNAGln biosynthesis via transamidation, carbon catabolite repression, catabolite repression, antibiotic anabolism, fatty acid breakdown, and mitochondrial translation. It localises to the glutamyl-tRNA(Gln) amidotransferase complex, mitochondria, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to glutamyl-tRNA(Gln) amidotransferase subunit A function and altered competitive fitness, starvation resistance, and chemical resistance phenotypes.