ipnA — Aspergillus nidulans FGSC A4

Summary

ANIA_02622 (ipnA) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a protein with isopenicillin-N synthase activity (EC 1.21.3.1) and 2-oxoglutarate dioxygenase activity, and binds iron, vitamin C, and metal. The gene is associated with regulation of penicillin anabolism, peptide anabolism, NAD breakdown, endocrocin anabolism, genetic transfer, sucrose breakdown, carbon catabolite repression, response to amino acid, small molecule biosynthesis, catabolite repression, penicillin anabolism, primary metabolism, secondary metabolism, pH reduction, fermentation, secondary metabolite biosynthesis, signal transduction, and homeostasis. The encoded protein localises to the cytosol. Related genes in other species link the isopenicillin-N synthase family to additional dioxygenase activities (EC 1.14.11.-, 1.14.-.-) and to proteins such as IPS, IPNS, and citB.