MAD2 — Aspergillus nidulans FGSC A4

Summary

ANIA_02511 (MAD2, AnMAD2) on Aspergillus nidulans chromosome 7 encodes a mitotic spindle checkpoint protein of the Mad2 family, containing a HORMA domain, and has been annotated with APC binding as its molecular function. The gene is associated with multiple cell cycle processes, including the spindle assembly checkpoint, mitotic chromosome segregation, and regulation of the metaphase/anaphase transition, as well as meiosis I spindle assembly checkpoint and mitotic DNA integrity checkpoint. It is linked to nuclear import, nuclear movement, and localisation at the kinetochore, mitotic spindle microtubule, spindle pole body, nucleoplasm, and nuclear periphery. Phenotypic associations include altered cell cycle progression, particularly in anaphase, decreased sporulation efficiency, absent spore wall formation, reduced colony sectoring, and altered resistance to chemicals. Studies of related genes in other species link the family to reduced virulence.