SKP1 — Aspergillus nidulans FGSC A4

Summary

ANIA_02302, designated AnSKP1 (also known as SCON-3), encodes a protein containing SKP1-like and BTB/POZ domains, with molecular functions including cullin family protein binding and glutathione binding. The gene is associated with diverse biological processes such as regulation of sulfur metabolism, carbon catabolite repression, protein ubiquitination, secondary metabolism, cell cycle modulation, and mitotic nuclear membrane biogenesis. It localizes to the cytoplasm, nucleus, and the RAVE complex. Phenotypic associations link AnSKP1 to cell cycle progression, including premature anaphase entry and altered G1/S and G2/M transitions, as well as decreased flocculation, abnormal bipolar budding, delayed sporulation, and increased mating efficiency. Related genes in other species connect the SKP1 family to nuclear SCF complex localization and oxidative stress response.