FLBC — Aspergillus nidulans FGSC A4

Summary

ANIA_02421 (FLBC, flbC) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a C2H2 zinc-finger protein with both DNA-binding transcription repressor and activator activity specific to RNA polymerase II. The gene is associated with the regulation of asexual sporulation, conidiophore development, conidium formation, and aerial mycelium formation, as well as fruiting body formation, developmental induction, and asexual reproduction. It has been linked to amylase release, autolysis, cellular responses to cold, acidic pH, metal, and mechanical stimulus, cellular stress response to acid chemicals, regulation of the apoptotic process and ergosterol biosynthetic process, and cellular zinc ion homeostasis. The product localises to both the cytoplasm and nucleus. Related genes in other species are linked to loss of pathogenicity and reduced virulence.