CSN5 — Aspergillus nidulans FGSC A4

Summary

ANIA_02129, symbol CSN5 (also known as csnE, JAB1, RRI1), encodes a metallopeptidase with deNEDDylase activity, belonging to the JAMM/MPN+ family and the COP9 signalosome complex. In Aspergillus nidulans, CSN5 is associated with COP9 signalosome assembly, protein deneddylation and neddylation, protein stabilization, and ubiquitin-dependent proteolysis. It is linked to cleistothecium development, asexual sporulation, hyphal growth, spore formation, and regulation of hypersensitivity. The gene has been connected to cell cycle modulation, secondary metabolism, isoprenoid and ergosterol anabolism, lipid metabolism regulation, and DNA anabolism. Localization evidence places the product in the cytoplasm, cytosol, nucleus, and the COP9 signalosome. Phenotypic associations include altered shmoo formation, mating efficiency, cell cycle progression (G1/S and G2/M phases), cell death, cell size, redox state, mitochondrial and peroxisomal distribution, flocculation, and vegetative growth rate. Studies of related genes in other species link the family to protein content.