CDC25 — Aspergillus nidulans FGSC A4

Summary

ANIA_02130, also known as CDC25, encodes a protein with Ras-like GEF and SH3 domains. In Aspergillus nidulans, this gene is associated with regulation of cell division, traversing the start control point of the mitotic cell cycle, and upregulation of exit from mitosis. It is linked to protein kinase A activation, adenylate cyclase-activating GPCR signaling, and cellular response to glucose stimulus. CDC25 is also associated with positive regulation of pheromone response MAPK cascade, conjugation with cellular fusion, and establishment or maintenance of cell polarity. The encoded protein localizes to the cytoplasm, plasmalemma, endosome membrane, and cellular bud. Studies of related genes in other species link the family to vacuolar protein sorting.