AOX — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene AOX (ANIA_02099, chromosome 7) encodes an alternative oxidase (AOX_sf family) with alternative oxidase activity, a metal-binding enzyme classified under EC 1.-.-.-. This mitochondrial inner membrane protein is associated with alternative respiration, the electron transport chain, oxidative phosphorylation, and ATP anabolism. It is also associated with sexual reproduction, syngamy, sporulation, cell growth regulation, heterotrophy, secondary metabolism, polyketide anabolism, gluconeogenesis, detoxification, secretion, and hypersensitivity. Related genes in other species link the family to oxidative stress response.