TLG2 — Aspergillus nidulans FGSC A4

Summary

ANIA_02048 (TLG2, tlgB) on chromosome 7 encodes a syntaxin-family SNARE protein with a T_SNARE domain. The gene product is associated with SNARE binding and is linked to vesicle fusion, Golgi-to-vacuole transport, vacuole fusion, cisternal maturation, Golgi organization, intracellular protein transport, secretion, and hyphal growth. It localizes to the Golgi membrane, Golgi cisterna, endosome membrane, late endosome, fungal-type vacuole membrane, and SNARE complex. Phenotypic associations include abnormal carbon and nitrogen source utilization, absent sporulation efficiency, decreased cell cycle progression, abnormal Golgi and vacuolar morphology, delayed autophagy and protein transport, increased adhesion, and altered cell death and nutrient uptake. Related genes in other species link the family to zinc, calcium, and acid sensitivity, potassium concentration, and oxidative stress response.