TSC13 — Aspergillus nidulans FGSC A4

Summary

AnTSC13 (ANIA_01968) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a very-long-chain enoyl-CoA reductase, a member of the SRD5A/TECR family with 3-oxo-5_a-steroid_4-DH_C domain, possessing very-long-chain enoyl-CoA reductase and trans-2-enoyl-CoA reductase (NADPH) activities. The gene is associated with very-long-chain fatty acid anabolism, fatty acid elongation, and sphingolipid metabolism and anabolism. Its product localises to the ER membrane, ER, and mitochondria. AnTSC13 is linked to numerous phenotypes including abnormal cell shape and budding pattern, decreased mating efficiency and response, absent autophagy and micronucleophagy, altered redox state, decreased acquired thermotolerance and alkaline pH resistance, increased telomere length, and abnormal ER morphology. Studies of related genes in other species connect it to calcium sensitivity and abnormal nuclear morphology.