ARP1 — Aspergillus nidulans FGSC A4

Summary

AnARP1 (ANIA_01953) on chromosome 7 encodes a structural constituent of the cytoskeleton with hydrolase activity and ATP binding, belonging to the actin/actin-like and ATPase NBD families. The gene is associated with nuclear migration along microtubules, nuclear transport, mitotic spindle assembly, microtubule assembly, RNA splicing, pigmentation and pigment anabolism. It localises to the cytoplasmic dynein and dynactin complexes, actin cytoskeleton, hyphal tip, site of polarised growth and cell tip. Phenotypic associations include abnormal lifespan, nuclear transport, chromosome segregation, septum formation, filamentous growth, cell cycle progression, and decreased cell fusion, nucleophagy and necrotic cell death, as well as increased mutation frequency and recovery from pheromone-induced arrest. Related genes in other species are linked to respiratory growth and acid sensitivity.