PPOA — Aspergillus nidulans FGSC A4

Summary

ANIA_01967 (PPOA, AnPPOA) on chromosome 7 encodes a protein with Ppo-like_N, haem peroxidase, cytochrome P450 and related domains. The enzyme possesses linoleate 8R-lipoxygenase, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase and fatty acid peroxidase activities (EC 1.13.11.60, 5.4.4.5). In Aspergillus nidulans, PPOA is associated with oxylipin, prostaglandin and phytosphingosine biosynthesis, regulation of hypersensitivity, cell wall thickening, fruiting body formation, and both positive regulation of asexual sporulation and negative regulation of sexual sporulation. The gene is also linked to penicillin metabolism, long-chain fatty acid and sphingolipid metabolism, and hydrogen peroxide catabolism. Studies of related genes in other species have connected the family to altered virulence, including hypervirulence and reduced virulence.