hulA — Aspergillus nidulans FGSC A4

Summary

ANIA_01874 (hulA) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a HECT-type E3 ubiquitin ligase (EC 2.3.2.26) with ubiquitin-protein transferase activity. The gene is associated with protein ubiquitination and polyubiquitination, ubiquitin-dependent proteolysis, and protein breakdown. It has been linked to vacuolar transport, including establishment of protein localization to the vacuole and protein-vacuolar targeting during ubiquitin-dependent breakdown via the MVB pathway. Additional associations include carbon catabolite repression, catabolite repression, deubiquitination, lipogenesis, detoxification, endocytosis, autophagy, and intracellular protein transport. The encoded protein localizes to the cytoplasm.