DUG2 — Aspergillus nidulans FGSC A4

Summary

ANIA_01879 (symbol DUG2, also known as AnARG-15) on Aspergillus nidulans chromosome 7 encodes a metallodipeptidase with protease activity and metal binding, belonging to the GSH_degradosome_Dug2 and peptidase M20 families. The gene is associated with glutathione breakdown, proteolysis, protein secretion, and mycotoxin (sterigmatocystin) anabolism. It localises to the cytoplasm, cytosol, and nucleus. Phenotypic associations include abnormal nutrient utilization, decreased sulfur and absent nitrogen source utilization, increased UV and metal resistance, altered colony appearance, increased replicative and chronological lifespan, decreased heat sensitivity and hyperosmotic stress resistance, and increased competitive fitness. The gene also links to altered vegetative growth, vacuolar morphology, and chemical compound accumulation. Studies of related genes in other species connect the family to dipeptidase activity and WD40-repeat protein function.