MYO1 — Aspergillus nidulans FGSC A4

Summary

ANIA_01558 (MYO1, AnMYO1) on chromosome 7 encodes a protein with a myosin head motor domain, SH3 domain, and microfilament motor activity. It binds F-actin and ATP and has hydrolase activity. The gene is associated with hyphal growth, cell tip growth, morphogenesis, chemotaxis, cell motility, endocytosis, exocytosis, pinocytosis, secretion, actin filament organization, actin cortical patch localization, cisternal maturation, homologous recombination, and ergosterol anabolism. It localizes to the hyphal tip, cell tip, actin patch, cross wall, actin cytoskeleton, myosin complex, microvillus, plasmalemma, and cytoplasm. Phenotypic associations include abnormal filamentous growth, absent spore germination, sterile, decreased cell fusion, abnormal budding and cytokinesis, delayed autophagy, decreased endocytosis, abnormal vesicle distribution, abnormal nuclear transport, abnormal plasma membrane morphology, decreased necrotic cell death, and absent innate thermotolerance. Studies of related genes in other species link the family to turgor pressure and potassium concentration.