OTA — Aspergillus nidulans FGSC A4

Summary

ANIA_01810 (OTA, also known as otaA, CAR2, ARG-5, ARG1, and ARG8) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a class-III pyridoxal-phosphate-dependent aminotransferase with L-ornithine transaminase and N2-acetylornithine 5-aminotransferase activities (EC 2.6.1.13). The gene is associated with arginine breakdown, ornithine metabolism, the urea cycle, L-proline biosynthesis, carbon catabolite repression, and mRNA breakdown. It is linked to chromatin modeling and localizes to the cytoplasm, cytosol, nucleus, and mitochondrial lumen. Phenotypic associations include altered cell cycle progression (G1 phase decreased duration, G2/M phase arrest, metaphase arrest), abnormal endocytosis, increased flocculation and biofilm formation, increased osmotic stress resistance, decreased freeze-thaw and ionic stress resistance, abnormal colony appearance and actin cytoskeleton morphology, and absent or decreased autophagy and sporulation.