PUT4 — Aspergillus nidulans FGSC A4

Summary

ANIA_01732 (PUT4, prnB) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes an amino acid permease belonging to the APC_YAT family, with experimentally confirmed L-proline, L-histidine, L-arginine, L-lysine, and basic amino acid transmembrane transporter activity, as well as amino acid binding. The gene is associated with proline transport, proline breakdown, response to proline and amino acid starvation, carbon catabolite repression, depurination, amino acid import and anabolism, and single-species biofilm formation. The encoded protein localizes to the plasma membrane, eisosome, fungal-type cell wall, Golgi, and ER. Phenotypic associations include decreased oxidative stress and toxin resistance, increased UV resistance, decreased chronological lifespan, abnormal vacuolar morphology, altered competitive fitness, and decreased vegetative growth rate. Related genes in other species are linked to reduced virulence and heat sensitivity.