SLN1 — Aspergillus nidulans FGSC A4

Summary

ANIA_01800 (SLN1, tcsB) on chromosome 7 of Aspergillus nidulans encodes a histidine kinase with osmosensor, peroxide sensor, and phosphorelay sensor kinase activities, as well as DNA-binding transcription factor activity. It is a membrane-associated protein localised to the plasma membrane, cytoplasm, and nucleus. The gene is associated with the high-osmolarity glycerol (HOG) response, response to singlet oxygen, regulation of conidium formation, filamentous growth, host invasion, fungal-type cell wall biogenesis, and iron-sulfur cluster assembly. Phenotypic associations include decreased hypoosmotic stress resistance, absent hyperosmotic stress resistance, altered cell cycle progression (including G1/S arrest and increased G2/M transition), decreased exponential growth, increased respiratory metabolism, and altered starvation resistance. Studies of related genes in other species link the family to turgor pressure, oxidative stress response, and reduced virulence.