prnB — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene prnB (ANIA_01581) on chromosome 7 encodes a proline transporter belonging to the amino acid permease family (APC_YAT, AA-permease/SLC12A_dom). The encoded protein exhibits L-proline, L-histidine, L-arginine, L-lysine, and basic amino acid transmembrane transporter activity, as well as amino acid binding. The gene is associated with proline transport, import, breakdown, and metabolism, along with responses to proline and amino acid starvation. It is also linked to carbon catabolite repression, depurination, amino acid anabolism, and biofilm formation. The protein localizes to the plasma membrane, eisosome, fungal-type cell wall, Golgi, and endoplasmic reticulum. Studies of related genes in other species link the family to reduced virulence.