CYT-18 — Aspergillus nidulans FGSC A4

Summary

ANIA_01709 (symbol CYT-18, preferred name AnCYT-18) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a tyrosine-tRNA ligase (EC 6.1.1.1) with RNA-binding and identical protein-binding activity. The gene is associated with tyrosyl-tRNA aminoacylation, tRNA charging, and RNA folding, as well as group I intron splicing, mRNA processing, and positive regulation of RNA splicing. The encoded protein localises to the mitochondrial lumen, mitochondria, and cytosol. Related genes in other species, including Verticillium dahliae and Fusarium oxysporum pathovars, are linked to similar RNA-processing and splicing functions, though these associations are not yet established for AnCYT-18 itself.