prnD — Aspergillus nidulans FGSC A4

Summary

ANIA_01731 (prnD) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a proline dehydrogenase, a FAD-linked oxidoreductase with proline oxidase activity (EC 1.5.5.2). The gene is associated with proline breakdown, carbon catabolite repression, cellular response to amino acid starvation, depurination, methylation, and chromatin modeling. Its product localises to the mitochondrial lumen and mitochondria. Related genes in other species, including Fusarium oxysporum and Verticillium dahliae, are linked to proline metabolism, though these associations are not yet established in A. nidulans.