CLM2 — Aspergillus nidulans FGSC A4

Summary

AnCLM2 (ANIA_01601) on chromosome 7 of Aspergillus nidulans encodes a cytochrome P450 monooxygenase with heme and iron binding, oxidoreductase activity, and aflatoxin B synthase activity. It is associated with fumagillin, aflatoxin, mycotoxin, ergosterol, and terpenoid anabolism, as well as sexual reproduction, meiosis, lipogenesis, fermentation, endocytosis, autophagy, and hypersensitivity. The gene is linked to numerous phenotypes including decreased micronucleophagy, nucleophagy, and ribophagy; increased cell death and fermentative metabolism; abnormal cell cycle progression and entry into G0; absent cytokinesis and hyperosmotic stress resistance; and arrested vegetative and exponential growth. It is also connected to decreased vacuolar transport and nutrient uptake, and increased lifespan. Studies of related genes in other species link the family to hypervirulence.