CLM2 — Aspergillus nidulans FGSC A4

Summary

ANIA_01397 (CLM2, AnCLM2) in Aspergillus nidulans FGSC A4 encodes a cytochrome P450 family protein with monooxygenase, oxidoreductase, and heme-iron binding activities, and is annotated for 3-hydroxyphenylacetate 6-hydroxylase and phenylacetate hydroxylase activity. It is associated with the endoplasmic reticulum membrane and linked to diverse biological processes including ergosterol, terpenoid, penicillin, and patulin biosynthesis, as well as sexual reproduction, meiosis, fermentation, lipogenesis, endocytosis, and autophagy. Phenotypic associations connect CLM2 to decreased micronucleophagy, nucleophagy, and ribophagy; increased cell death and fermentative metabolism; abnormal cell cycle progression and G0 entry; arrested vegetative and exponential growth; increased lifespan; and altered stress resistance, nutrient utilization, and organelle distribution. Related genes in other species link the family to sterol 14α-demethylase activity and ergosterol pathway components.