HEX1 — Aspergillus nidulans FGSC A4

Summary

ANIA_01502 (HEX1, AnHEX1) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a beta-N-acetylhexosaminidase (EC 3.2.1.52), a glycoside hydrolase family 20 protein with a eukaryotic HEX_N domain. The enzyme has hexosaminidase and beta-N-acetylglucosaminidase activity. It is associated with chitobiose catabolism, N-acetylglucosamine breakdown, glycosaminoglycan metabolism, polysaccharide breakdown, and general carbohydrate metabolism. The gene product is linked to autolysis and cell death, and localises to the extracellular space and membrane. Studies of related genes in other species connect the family to reduced virulence and to protein content traits.