CP1 — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene CP1 (ANIA_01426) on chromosome 7 encodes a serine carboxypeptidase (EC 3.4.16.-) belonging to the peptidase S10 family. The encoded protein is associated with proteolysis, intracellular transport, regulation of gene expression, chromatin organization, methylation, and homeostasis. It localizes to the fungal-type vacuole, plasma membrane, extracellular region, and side of membrane. The gene is linked to numerous cellular processes, including autophagy, mitophagy, pexophagy, ribophagy, endocytosis, cytokinesis, protein secretion, nuclear fusion during mating, and cell death. Associations with increased acquired thermotolerance, altered prion inheritance, abnormal Golgi morphology, and changes in replicative lifespan and chemical compound accumulation have also been observed. Related genes in other species link the family to apoplastic effector functions.