NAG1 — Aspergillus nidulans FGSC A4

Summary

AnNAG1 (NAG1) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a glucosamine-6-phosphate isomerase (EC 3.5.99.6), a cytoplasmic enzyme with glucosamine-6-phosphate deaminase activity and identical protein binding capability. The gene is associated with the breakdown of N-acetylneuraminate, glucosamine, N-acetylglucosamine, and chitin, as well as with carbohydrate metabolism, filamentous growth, filamentous growth in response to biotic stimulus, and osmotic response. Studies of related genes in other species link the family to reduced virulence and glucose content, though these associations are not established for AnNAG1 itself.